• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a process for the preparation of hydroxylamine derivatives of the general formula R, -NrOK} -CHi-CKtOU-C CH-CR CtNH2 -CR, where R is Cl, CN; R, - H, Cl; Rj is Cz-4-alkyl (it may be substituted by OH), or their salts, which can be used in agriculture as a means to increase the productivity of animals. The goal is to create new, more active compounds of the specified class. The synthesis of the target substances is carried out by reduction of the compound of the general formula RN - (0) CH-CGO JC H-CR C / NH 2 / - -CR, CH, where R, R and R - have the above values using alkali metal boron. environment of an inert organic solvent, followed by the allocation of the target product in free form or in the form of a salt. New compounds in a concentration of 0.0025% increase the weight of rats in 13 days by 43.0-47.3 g versus 36.4 g for control and 40.7 g for a known substance. 2 tab. § ABOUT)
    公开号:SU1456007A3
    申请号:SU864027698
    申请日:1986-06-27
    公开日:1989-01-30
    发明作者:Ингендох Аксель；Линдель Ганс；Бершауер Фридрих；Де Ионг Анно；Шеер Мартин
    申请人:Байер Аг (Фирма)；
    IPC主号:
    专利说明:

    Feeding experience rats.
    Female rats weighing 90–110 g (SPF Wistar type) are fed with standard rat food containing 0.0025% of the test active substance, with food of identical composition used for each experiment. Animals are given water at will.
    Each group includes 12 experimental rats. The control group is given feed without the addition of the active substance. In all groups, the average weight and the difference in weight are the same, due to which comparability of groups of experimental animals is provided.
    The weight gain is determined over the 13 days of the experiment.
    For comparison, the experiment was carried out using the known substance L-tert-butyl-H-2-hydroxy-2- (3,5-dichloro-4-aminophenyl) -ethanolamine (A).
    Active substance Weight gain, g
    according to example 147.3
    245.5
    ,one
    , 0,. AAO, 7
    Control36,4
    New derivatives of hydroxylamine belong to the category of low-toxic substances.
    As can be seen from the above data, the proposed method allows to obtain compounds that allow a greater degree of increase in the productivity of animals compared with the known ones.
    权利要求:
    Claims (1)
    [1]
    Formula iso
    The method of obtaining hydroxylamine derivatives of the general formula
    HE
    he 6n-CH2-2 - g
    55
    where R is chlorine, dianogroup;
    R, is hydrogen, chlorine
    R - Cj-C-alkyl, unsubstituted
    or substituted by hydroxyl, or their salts, distinguishing-- so that the compound of the general formula
    five
    salt.
    Rproduct in free form or as
    one
    where R, R ,, R have the specified values
    , 14560076
    subjected to recovery with the help of an alkali metal borane in an inert organic solvent, followed by the allocation of the target
    five
    salt.
    product in free form or as
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    同族专利:
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    PT82932B|1988-07-01|
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    DE3660809D1|1988-11-03|
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    EP0209025B1|1988-09-28|
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    CS258485B2|1988-08-16|
    FI862943A|1987-01-17|
    DK335486A|1987-01-17|
    JPS6219557A|1987-01-28|
    DK335486D0|1986-07-15|
    ES2004158A6|1988-12-16|
    DE3525336A1|1987-01-22|
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB1062299A|1965-02-19|1967-03-22|Lepetit Spa|3,4-dihydroxyphenyl-propane derivatives|
    DE2351281C3|1973-10-12|1981-07-30|Dr. Karl Thomae Gmbh, 7950 Biberach|Aminophenylethanolamine derivatives, their production and use|
    IL60530A|1979-08-16|1984-10-31|American Cyanamid Co|Animal feed compositions useful as growth promotors and for reduction of fat in animals,comprising phenylethanolamine derivatives and certain such novel compounds|
    US4407819A|1980-08-25|1983-10-04|American Cyanamid Company|Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals|
    GB2137619A|1983-03-30|1984-10-10|Gerald Scott|Nitrone compounds and stabilised rubber compositions containing them|
    DE3525336A1|1985-07-16|1987-01-22|Bayer Ag|ARYLETHANOLHYDROXYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR PROMOTING PERFORMANCE|DE3525336A1|1985-07-16|1987-01-22|Bayer Ag|ARYLETHANOLHYDROXYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR PROMOTING PERFORMANCE|
    DE3678252D1|1985-10-17|1991-04-25|American Cyanamid Co|ANTHRANILONITRILE DERIVATIVES AND RELATED COMPOUNDS AS USEFUL SUBSTANCES FOR ACCELERATING GROWTH, FOR IMPROVING THE QUALITY OF FOOD AND FOR INCREASING THE MEAT / FAT RATIO IN WARM BLOODED ANIMALS.|
    DE3623940A1|1986-07-16|1988-01-21|Bayer Ag|ARYLETHANOLHYDROXYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR PROMOTING PERFORMANCE|
    US4749733A|1986-12-12|1988-06-07|Ciba-Geigy Corporation|Substituted hydroxylamines and compositions stabilized therewith|
    US4918189A|1986-12-12|1990-04-17|Ciba-Geigy Corporation|Substituted hydroxylamines and compositions stabilized therewith|
    DE3725084A1|1987-07-29|1989-02-09|Bayer Ag|SUBSTITUTED PYRIDINETHANOLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AN PERFORMANCE IN ANIMALS|
    US5406000A|1993-01-12|1995-04-11|Elf/Atochem North America, Inc.|Process for the production of 3-aminomethyl-3,5,5-trialkylcyclohexylamine|
    US5508155A|1994-12-22|1996-04-16|Eastman Kodak Company|Photographic color developers containing odorless antioxidants formed in situ from reaction of hydroxylamine and epoxide and use of same|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE19853525336|DE3525336A1|1985-07-16|1985-07-16|ARYLETHANOLHYDROXYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR PROMOTING PERFORMANCE|
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